Genomics-aided structure prediction.
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ABSTRACT:
SUBMITTER: Sulkowska JI
PROVIDER: S-EPMC3387073 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Genomics-aided structure prediction.
Sułkowska Joanna I JI Morcos Faruck F Weigt Martin M Hwa Terence T Onuchic José N JN
Proceedings of the National Academy of Sciences of the United States of America 20120612 26
We introduce a theoretical framework that exploits the ever-increasing genomic sequence information for protein structure prediction. Structure-based models are modified to incorporate constraints by a large number of non-local contacts estimated from direct coupling analysis (DCA) of co-evolving genomic sequences. A simple hybrid method, called DCA-fold, integrating DCA contacts with an accurate knowledge of local information (e.g., the local secondary structure) is sufficient to fold proteins ...[more]
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