Ontology highlight
ABSTRACT: ConclusionsWe have identified 2 SNPs associated with earlier onset of childhood asthma in 4 independent cohorts.Background
Childhood asthma is a complex disease with known heritability and phenotypic diversity. Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children.Objective
We sought to identify genetic variants associated with earlier onset of childhood asthma.Methods
We conducted the first genome-wide association study of the age of onset of childhood asthma among participants in the Childhood Asthma Management Program (CAMP) and used 3 independent cohorts from North America, Costa Rica, and Sweden for replication.Results
Two single nucleotide polymorphisms (SNPs) were associated with earlier onset of asthma in the combined analysis of CAMP and the replication cohorts: rs9815663 (Fisher P= 2.31 × 10(-8)) and rs7927044 (P= 6.54 × 10(-9)). Of these 2 SNPs, rs9815663 was also significantly associated with earlier asthma onset in an analysis including only the replication cohorts. Ten SNPs in linkage disequilibrium with rs9815663 were also associated with earlier asthma onset (2.24 × 10(-7)
SUBMITTER: Forno E
PROVIDER: S-EPMC3387331 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Forno Erick E Lasky-Su Jessica J Himes Blanca B Howrylak Judie J Ramsey Clare C Brehm John J Klanderman Barbara B Ziniti John J Melén Erik E Pershagen Goran G Wickman Magnus M Martinez Fernando F Mauger Dave D Sorkness Christine C Tantisira Kelan K Raby Benjamin A BA Weiss Scott T ST Celedón Juan C JC
The Journal of allergy and clinical immunology 20120502 1
<h4>Background</h4>Childhood asthma is a complex disease with known heritability and phenotypic diversity. Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children.<h4>Objective</h4>We sought to identify genetic variants associated with earlier onset of childhood asthma.<h4>Methods</h4>We conducted the first genome-wide association study of the age of onset of childhood asthma among participa ...[more]