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Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study.


ABSTRACT: BACKGROUND:Childhood asthma is strongly influenced by genetics and is a risk factor for reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This study investigates self-reported childhood asthma in adult smokers from the COPDGene Study. We hypothesize that childhood asthma is associated with decreased lung function, increased risk for COPD, and that a genome-wide association study (GWAS) will show association with established asthma variants. METHODS:We evaluated current and former smokers ages 45-80 of non-Hispanic white (NHW) or African American (AA) race. Childhood asthma was defined by self-report of asthma, diagnosed by a medical professional, with onset at

SUBMITTER: Hayden LP 

PROVIDER: S-EPMC6206739 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study.

Hayden Lystra P LP   Cho Michael H MH   Raby Benjamin A BA   Beaty Terri H TH   Silverman Edwin K EK   Hersh Craig P CP  

Respiratory research 20181029 1


<h4>Background</h4>Childhood asthma is strongly influenced by genetics and is a risk factor for reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This study investigates self-reported childhood asthma in adult smokers from the COPDGene Study. We hypothesize that childhood asthma is associated with decreased lung function, increased risk for COPD, and that a genome-wide association study (GWAS) will show association with established asthma variants.<h4>Methods</h4>  ...[more]

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