Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination.
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ABSTRACT:
SUBMITTER: Gomes NM
PROVIDER: S-EPMC3387546 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination.
Gomes Nuno M V NM Ryder Oliver A OA Houck Marlys L ML Charter Suellen J SJ Walker William W Forsyth Nicholas R NR Austad Steven N SN Venditti Chris C Pagel Mark M Shay Jerry W JW Wright Woodring E WE
Aging cell 20110601 5
Progressive telomere shortening from cell division (replicative aging) provides a barrier for human tumor progression. This program is not conserved in laboratory mice, which have longer telomeres and constitutive telomerase. Wild species that do/do not use replicative aging have been reported, but the evolution of different phenotypes and a conceptual framework for understanding their uses of telomeres is lacking. We examined telomeres/telomerase in cultured cells from > 60 mammalian species to ...[more]
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