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Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds.

ABSTRACT: Two-directional synthesis represents an ideal strategy for the rapid elaboration of simple starting materials and their subsequent transformation into complex molecular architectures. As such, it is becoming recognised as an enabling technology for diversity-oriented synthesis. Herein, we provide a thorough account of our work combining two-directional synthesis with diversity-oriented synthesis, with particular reference to the synthesis of polycyclic alkaloid scaffolds.

SUBMITTER: O'Connell KM

PROVIDER: S-EPMC3388873 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds.

O'Connell Kieron M G KM Díaz-Gavilán Monica M Galloway Warren R J D WR Spring David R DR

Beilstein journal of organic chemistry 20120606

Two-directional synthesis represents an ideal strategy for the rapid elaboration of simple starting materials and their subsequent transformation into complex molecular architectures. As such, it is becoming recognised as an enabling technology for diversity-oriented synthesis. Herein, we provide a thorough account of our work combining two-directional synthesis with diversity-oriented synthesis, with particular reference to the synthesis of polycyclic alkaloid scaffolds. ...[more]

PMID: 23015833

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