Ontology highlight
ABSTRACT:
SUBMITTER: Martin ED
PROVIDER: S-EPMC3388895 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Martín Eduardo D ED Sánchez-Perez Ana A Trejo José Luis JL Martin-Aldana Juan Antonio JA Cano Jaimez Marife M Pons Sebastián S Acosta Umanzor Carlos C Menes Lorena L White Morris F MF Burks Deborah J DJ
Cerebral cortex (New York, N.Y. : 1991) 20110927 8
The beneficial effects of insulin and insulin-like growth factor I on cognition have been documented in humans and animal models. Conversely, obesity, hyperinsulinemia, and diabetes increase the risk for neurodegenerative disorders including Alzheimer's disease (AD). However, the mechanisms by which insulin regulates synaptic plasticity are not well understood. Here, we report that complete disruption of insulin receptor substrate 2 (Irs2) in mice impairs long-term potentiation (LTP) of synaptic ...[more]