Ontology highlight
ABSTRACT:
SUBMITTER: Nabavi S
PROVIDER: S-EPMC3593861 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Nabavi Sadegh S Kessels Helmut W HW Alfonso Stephanie S Aow Jonathan J Fox Rocky R Malinow Roberto R
Proceedings of the National Academy of Sciences of the United States of America 20130219 10
NMDA receptor (NMDAR) activation controls long-term potentiation (LTP) as well as long-term depression (LTD) of synaptic transmission, cellular models of learning and memory. A long-standing view proposes that a high level of Ca(2+) entry through NMDARs triggers LTP; lower Ca(2+) entry triggers LTD. Here we show that ligand binding to NMDARs is sufficient to induce LTD; neither ion flow through NMDARs nor Ca(2+) rise is required. However, basal levels of Ca(2+) are permissively required. Lowerin ...[more]