Ontology highlight
ABSTRACT:
SUBMITTER: Kim YM
PROVIDER: S-EPMC3389276 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Molecular cell 20120509 6
Amino acids stimulate cell growth and suppress autophagy through activation of mTORC1. The activation of mTORC1 by amino acids is mediated by Rag guanosine triphosphatase (GTPase) heterodimers on the lysosome. The molecular mechanism by which amino acids regulate the Rag GTPase heterodimers remains to be elucidated. Here, we identify SH3 domain-binding protein 4 (SH3BP4) as a binding protein and a negative regulator of Rag GTPase complex. SH3BP4 binds to the inactive Rag GTPase complex through i ...[more]