Ontology highlight
ABSTRACT:
SUBMITTER: Feng D
PROVIDER: S-EPMC3389392 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Feng Dan D Liu Tao T Sun Zheng Z Bugge Anne A Mullican Shannon E SE Alenghat Theresa T Liu X Shirley XS Lazar Mitchell A MA
Science (New York, N.Y.) 20110301 6022
Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays a circadian rhythm in mouse liver. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Although amounts of HDAC3 are constant, its genomic recruitment in liver corresponds to the expression pattern of the circadian nuclear receptor Rev-erbα. Rev-erbα colocalizes with HDA ...[more]