Ontology highlight
ABSTRACT:
SUBMITTER: Coomans CP
PROVIDER: S-EPMC3609590 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Coomans Claudia P CP van den Berg Sjoerd A A SA van den Berg Sjoerd A A SA Lucassen Eliane A EA Houben Thijs T Pronk Amanda C M AC van der Spek Rianne D RD Kalsbeek Andries A Biermasz Nienke R NR Willems van Dijk Ko K Romijn Johannes A JA Meijer Johanna H JH
Diabetes 20121228 4
Disturbances in the circadian system are associated with the development of type 2 diabetes mellitus. Here, we studied the direct contribution of the suprachiasmatic nucleus (SCN), the central pacemaker in the circadian system, in the development of insulin resistance. Exclusive bilateral SCN lesions in male C57Bl/6J mice, as verified by immunochemistry, showed a small but significant increase in body weight (+17%), which was accounted for by an increase in fat mass. In contrast, mice with colla ...[more]