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ABSTRACT:
SUBMITTER: Kozhukh J
PROVIDER: S-EPMC3389809 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Kozhukh Julia J Lippard Stephen J SJ
Inorganic chemistry 20120615 13
Zinc thiolate complexes containing N(2)S tridentate ligands were prepared to investigate their reactivity toward reactive nitrogen species, chemistry proposed to occur at the zinc tetracysteine thiolate site of nitric oxide synthase (NOS). The complexes are unreactive toward nitric oxide (NO) in the absence of dioxygen, strongly indicating that NO cannot be the species directly responsible for S-nitrosothiol formation and loss of Zn(2+) at the NOS dimer interface in vivo. S-Nitrosothiol formatio ...[more]