MTOR: from growth signal integration to cancer, diabetes and ageing.
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ABSTRACT:
SUBMITTER: Zoncu R
PROVIDER: S-EPMC3390257 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
mTOR: from growth signal integration to cancer, diabetes and ageing.
Zoncu Roberto R Efeyan Alejo A Sabatini David M DM
Nature reviews. Molecular cell biology 20101215 1
In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt. In the past few years, a significant advance in our understanding of the regulati ...[more]
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