Ontology highlight
ABSTRACT:
SUBMITTER: Himes BE
PROVIDER: S-EPMC3390407 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Himes Blanca E BE Jiang Xiaofeng X Hu Ruoxi R Wu Ann C AC Lasky-Su Jessica A JA Klanderman Barbara J BJ Ziniti John J Senter-Sylvia Jody J Lima John J JJ Irvin Charles G CG Peters Stephen P SP Meyers Deborah A DA Bleecker Eugene R ER Kubo Michiaki M Tamari Mayumi M Nakamura Yusuke Y Szefler Stanley J SJ Lemanske Robert F RF Zeiger Robert S RS Strunk Robert C RC Martinez Fernando D FD Hanrahan John P JP Koppelman Gerard H GH Postma Dirkje S DS Nieuwenhuis Maartje A E MA Vonk Judith M JM Panettieri Reynold A RA Markezich Amy A Israel Elliot E Carey Vincent J VJ Tantisira Kelan G KG Litonjua Augusto A AA Lu Quan Q Weiss Scott T ST
PLoS genetics 20120705 7
Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV(1)) before and after the administration of a short-acting β(2)-agonist, the most common rescue medications used for the treatment of asthma. BDR also serves as a test of β(2)-agonist efficacy. BDR is a complex trait that is partly under genetic control. A genome-wide association study (GWAS) of BDR, quantified as percent change in baseline FEV(1) a ...[more]