Ontology highlight
ABSTRACT:
SUBMITTER: Duan QL
PROVIDER: S-EPMC3706515 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Duan Q L QL Lasky-Su J J Himes B E BE Qiu W W Litonjua A A AA Damask A A Lazarus R R Klanderman B B Irvin C G CG Peters S P SP Hanrahan J P JP Lima J J JJ Martinez F D FD Mauger D D Chinchilli V M VM Soto-Quiros M M Avila L L Celedón J C JC Lange C C Weiss S T ST Tantisira K G KG
The pharmacogenomics journal 20130319 1
Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) to inhaled albuterol, 534 290 single-nucleotide polymorphisms (SNPs) were tested in 403 white trios from the Childhood Asthma Management Program using five statistical models to determine the most robust genetic associations. The primary replication phase included 1397 polymo ...[more]