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Labdane diterpenoids from Leonotis leonurus.

ABSTRACT: Three known (leoleorins A-C) and eight hitherto unknown (leoleorins D-J and 16-epi-leoleorin F) labdane diterpenoids, were isolated from leaves of Leonotis leonurus. The absolute configurations of leoleorins A and D were established by X-ray crystallographic analyses. In a competitive binding assay, all isolated compounds showed inhibition in excess of 50% at various CNS receptors. Leoleorin C showed moderate binding affinity (Ki=2.9 ?M) for the Sigma 1 receptor.

SUBMITTER: Wu H

PROVIDER: S-EPMC3390464 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Labdane diterpenoids from Leonotis leonurus.

Wu Hankui H Li Jun J Fronczek Frank R FR Ferreira Daneel D Burandt Charles L CL Setola Vincent V Roth Bryan L BL Zjawiony Jordan K JK

Phytochemistry 20120321

Three known (leoleorins A-C) and eight hitherto unknown (leoleorins D-J and 16-epi-leoleorin F) labdane diterpenoids, were isolated from leaves of Leonotis leonurus. The absolute configurations of leoleorins A and D were established by X-ray crystallographic analyses. In a competitive binding assay, all isolated compounds showed inhibition in excess of 50% at various CNS receptors. Leoleorin C showed moderate binding affinity (Ki=2.9 μM) for the Sigma 1 receptor. ...[more]

PMID: 22445074

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