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Leonurenones A-C: Labdane diterpenes from Leonotis leonurus.

ABSTRACT: Labdanes, leonurenones A-C, two known labdanes, luteolin 7-O-?-glucoside and luteolin were isolated and characterized from a commercial source of Leonotis leonurus. Genetic methods allowed for identification of the plant material. The leonurenones contain an uncommon ?,?-unsaturated enone moiety in ring B, and leonurenones A and B were evaluated in a competitive inhibition assay at the GABA A neuroreceptor site.

SUBMITTER: He F

PROVIDER: S-EPMC3685147 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Leonurenones A-C: Labdane diterpenes from Leonotis leonurus.

He Fang F Lindqvist Charlotte C Harding Wayne W WW

Phytochemistry 20120812

Labdanes, leonurenones A-C, two known labdanes, luteolin 7-O-β-glucoside and luteolin were isolated and characterized from a commercial source of Leonotis leonurus. Genetic methods allowed for identification of the plant material. The leonurenones contain an uncommon α,β-unsaturated enone moiety in ring B, and leonurenones A and B were evaluated in a competitive inhibition assay at the GABA A neuroreceptor site. ...[more]

PMID: 22892215

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