T1R3: a human calcium taste receptor.
Ontology highlight
ABSTRACT:
SUBMITTER: Tordoff MG
PROVIDER: S-EPMC3390595 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
T1R3: a human calcium taste receptor.
Tordoff Michael G MG Alarcón Laura K LK Valmeki Sitaram S Jiang Peihua P
Scientific reports 20120706
Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by lactisole, an inhibitor of hT1R3. Moreover, trained volunteers report that lactisole reduces the calcium intensity of calcium lactate. Thus, humans can detect calcium by taste, T1R3 is a receptor responsible for this, and lactisole can reduce the taste perception of calcium by acting on ...[more]
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