Ontology highlight
ABSTRACT:
SUBMITTER: Clausen TM
PROVIDER: S-EPMC3390611 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Clausen Thomas M TM Christoffersen Stig S Dahlbäck Madeleine M Langkilde Annette Eva AE Jensen Kamilla E KE Resende Mafalda M Agerbæk Mette Ø MØ Andersen Daniel D Berisha Besim B Ditlev Sisse B SB Pinto Vera V VV Nielsen Morten A MA Theander Thor G TG Larsen Sine S Salanti Ali A
The Journal of biological chemistry 20120508 28
Malaria is a major global health problem. Pregnant women are susceptible to infection regardless of previously acquired immunity. Placental malaria is caused by parasites capable of sequestering in the placenta. This is mediated by VAR2CSA, a parasite antigen that interacts with chondroitin sulfate A (CSA). One vaccine strategy is to block this interaction with VAR2CSA-specific antibodies. It is a priority to define a small VAR2CSA fragment that can be used in an adhesion blocking vaccine. In th ...[more]