Ontology highlight
ABSTRACT:
SUBMITTER: Ayres Pereira M
PROVIDER: S-EPMC4996535 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Ayres Pereira Marina M Mandel Clausen Thomas T Pehrson Caroline C Mao Yang Y Resende Mafalda M Daugaard Mads M Riis Kristensen Anders A Spliid Charlotte C Mathiesen Line L E Knudsen Lisbeth L Damm Peter P G Theander Thor T R Hansson Stefan S A Nielsen Morten M Salanti Ali A
PLoS pathogens 20160824 8
During placental malaria, Plasmodium falciparum infected erythrocytes sequester in the placenta, causing health problems for both the mother and fetus. The specific adherence is mediated by the VAR2CSA protein, which binds to placental chondroitin sulfate (CS) on chondroitin sulfate proteoglycans (CSPGs) in the placental syncytium. However, the identity of the CSPG core protein and the cellular impact of the interaction have remain elusive. In this study we identified the specific CSPG core prot ...[more]