Ontology highlight
ABSTRACT:
SUBMITTER: Tash BR
PROVIDER: S-EPMC3390843 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Tash Brian R BR Bewley Maria C MC Russo Mariano M Keil Jason M JM Griffin Kathleen A KA Sundstrom Jeffrey M JM Antonetti David A DA Tian Fang F Flanagan John M JM
Proceedings of the National Academy of Sciences of the United States of America 20120618 27
Tight junctions (TJs) are dynamic cellular structures that are critical for compartmentalizing environments within tissues and regulating transport of small molecules, ions, and fluids. Phosphorylation-dependent binding of the transmembrane protein occludin to the structural organizing protein ZO-1 contributes to the regulation of barrier properties; however, the details of their interaction are controversial. Using small angle X-ray scattering (SAXS), NMR chemical shift perturbation, cross-satu ...[more]