Ontology highlight
ABSTRACT:
SUBMITTER: Yu Z
PROVIDER: S-EPMC3391095 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Yu Zhipeng Z Fan Dongsheng D Gui Bin B Shi Lei L Xuan Chenghao C Shan Lin L Wang Qian Q Shang Yongfeng Y Wang Yan Y
The Journal of biological chemistry 20120514 27
Despite the identification of the 43 kDa transactive response DNA-binding protein (TDP-43) as a major pathological signatory protein in a wide range of neurodegenerative diseases, the mechanistic role of TDP-43 in neurodegenerative disorders is still poorly understood. Here, we report that TDP-43 is physically associated with fragile X mental retardation protein (FMRP) and Staufen (STAU1) to form a functional complex. Differential microarray analysis revealed that the expression of a collection ...[more]