Ontology highlight
ABSTRACT:
SUBMITTER: Ryu MJ
PROVIDER: S-EPMC3391097 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Ryu Myung-Jeom MJ Liu Yangang Y Zhong Xiaofen X Du Juan J Peterson Nicholas N Kong Guangyao G Li Hongda H Wang Jinyong J Salamat Shahriar S Chang Qiang Q Zhang Jing J
The Journal of biological chemistry 20120510 27
Previous studies suggest that up-regulation of Ras signaling in neurons promotes gliosis and astrocytoma formation in a cell nonautonomous manner. However, the underlying mechanisms remain unknown. To address this question, we generated compound mice (LSL Kras G12D/+;CamKII-Cre) that express oncogenic Kras from its endogenous locus in postmitotic neurons after birth. These mice developed progressive gliosis, which is associated with hyperactivation of Ras signaling pathways. Microarray analysis ...[more]