Ontology highlight
ABSTRACT:
SUBMITTER: Mulepati S
PROVIDER: S-EPMC3391111 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Mulepati Sabin S Orr Amberly A Bailey Scott S
The Journal of biological chemistry 20120523 27
Prokaryotes make use of small RNAs encoded by CRISPR (clustered regularly interspaced short palindromic repeat) loci to provide immunity against bacteriophage or plasmid invasion. In Escherichia coli, the CRISPR-associated complex for antiviral defense (Cascade) utilizes these RNAs to target foreign DNA for destruction. CasA, the largest subunit of Cascade, is essential for its function. Here we report the crystal structure of Thermus thermophilus CasA. The structure is composed of two domains t ...[more]