Ontology highlight
ABSTRACT:
SUBMITTER: Massimi P
PROVIDER: S-EPMC3391271 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Massimi Paola P Zori Patrizia P Roberts Sally S Banks Lawrence L
PloS one 20120706 7
The components of the Scrib/Dlg tumour suppressor complex have complementary roles in Drosophila and loss of both proteins is a common event in many different human tumours. However no studies have directly addressed the respective contributions of loss of hScrib and hDlg in the same human cell background to cellular phenotypes associated with cell transformation. In human HaCaT keratinocytes we show that removal of hScrib greatly reduces cell-cell contact and cell-matrix interactions, and promo ...[more]