Ontology highlight
ABSTRACT:
SUBMITTER: Gattinoni L
PROVIDER: S-EPMC3393131 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Gattinoni Luca L Ji Yun Y Restifo Nicholas P NP
Clinical cancer research : an official journal of the American Association for Cancer Research 20100805 19
Wnt ligands are lipid-modified secreted glycoproteins that regulate embryonic development, cell fate specification, and the homeostasis of self-renewing adult tissues. In addition to its well-established role in thymocyte development, recent studies have indicated that Wnt/β-catenin signaling is critical for the differentiation, polarization, and survival of mature T lymphocytes. Here, we describe our current understanding of Wnt signaling in the biology of post-thymic T cells, and discuss how h ...[more]