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HIV-1 tropism evolution after short-term maraviroc monotherapy in HIV-1-infected patients.

ABSTRACT: We analyzed the evolution of viral tropism after 8 days of maraviroc monotherapy, i.e., we used the maraviroc clinical test (MCT), in 21 patients with and 14 without virological response to the drug (MCT(+) and MCT(-) patients, respectively). No increases in CXCR4 inferred viral loads (X4IVLs) were observed in MCT(+) patients, while X4IVLs increased only in MCT(-) patients, with X4IVLs of >2 log(10) HIV RNA copies/ml. These results shed light on the evolution of viral tropism under a CCR5 antagonist in vivo.

SUBMITTER: Gonzalez-Serna A 

PROVIDER: S-EPMC3393450 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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HIV-1 tropism evolution after short-term maraviroc monotherapy in HIV-1-infected patients.

Gonzalez-Serna Alejandro A   Romero-Sánchez María Concepción MC   Ferrando-Martinez Sara S   Genebat Miguel M   Vidal Francesc F   Muñoz-Fernández Maria Ángeles MÁ   Abad María Antonia MA   Leal Manuel M   Ruiz-Mateos Ezequiel E  

Antimicrobial agents and chemotherapy 20120430 7

We analyzed the evolution of viral tropism after 8 days of maraviroc monotherapy, i.e., we used the maraviroc clinical test (MCT), in 21 patients with and 14 without virological response to the drug (MCT(+) and MCT(-) patients, respectively). No increases in CXCR4 inferred viral loads (X4IVLs) were observed in MCT(+) patients, while X4IVLs increased only in MCT(-) patients, with X4IVLs of >2 log(10) HIV RNA copies/ml. These results shed light on the evolution of viral tropism under a CCR5 antago  ...[more]

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