Validation of the HIV Tropism Test TROCAI Using the Virological Response to a Short-Term Maraviroc Monotherapy Exposure.
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SUBMITTER: Gonzalez-Serna A
PROVIDER: S-EPMC5038326 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
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Validation of the HIV Tropism Test TROCAI Using the Virological Response to a Short-Term Maraviroc Monotherapy Exposure.
Gonzalez-Serna A A Genebat M M De Luna-Romero M M Tarancon-Diez L L Dominguez-Molina B B Pacheco Y M YM Muñoz-Fernández M A MA Leal M M Ruiz-Mateos E E
Antimicrobial agents and chemotherapy 20160923 10
TROCAI is a phenotypic tropism test developed using the virological response to a short-term exposure to maraviroc monotherapy (Maraviroc Clinical Test [MCT]). It was found that with TROCAI, a cutoff of <0.5% of dual/mixed viruses was needed to predict R5 HIV tropism. Here, we have validated TROCAI, using this cutoff, in a new cohort of 42 patients, finding a very high concordance between TROCAI and MCT (98%), and a good concordance (71 to 87%) with other genotypic/phenotypic methods. ...[more]
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