No association of candidate genes with cannabis use in a large sample of Australian twin families.
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ABSTRACT:
SUBMITTER: Verweij KJ
PROVIDER: S-EPMC3393887 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
No association of candidate genes with cannabis use in a large sample of Australian twin families.
Verweij Karin J H KJ Zietsch Brendan P BP Liu Jimmy Z JZ Medland Sarah E SE Lynskey Michael T MT Madden Pamela A F PA Agrawal Arpana A Montgomery Grant W GW Heath Andrew C AC Martin Nicholas G NG
Addiction biology 20110420 3
While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neu ...[more]
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