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Genome-wide association study of height and body mass index in Australian twin families.

ABSTRACT: Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at approximately 550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value=1.06x10(-9)) located in HHIP, a well-replicated height-associated gene. Suggestive levels of association were found for other known genes associated with height (P values<1x10(-6)): ADAMTSL3, EFEMP1, GPR126, and HMGA2; and BMI (P values<1x10(-4)): FTO and MC4R. Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI.

SUBMITTER: Liu JZ 

PROVIDER: S-EPMC3232006 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Genome-wide association study of height and body mass index in Australian twin families.

Liu Jimmy Z JZ   Medland Sarah E SE   Wright Margaret J MJ   Henders Anjali K AK   Heath Andrew C AC   Madden Pamela A F PA   Duncan Alexis A   Montgomery Grant W GW   Martin Nicholas G NG   McRae Allan F AF  

Twin research and human genetics : the official journal of the International Society for Twin Studies 20100401 2

Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at approximately 550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value=1.06x10(-9)) located in HHIP, a well-replicated height  ...[more]

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