Unknown

Dataset Information

0

Genome-wide association study of height and body mass index in Australian twin families.

ABSTRACT: Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at approximately 550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value=1.06x10(-9)) located in HHIP, a well-replicated height-associated gene. Suggestive levels of association were found for other known genes associated with height (P values<1x10(-6)): ADAMTSL3, EFEMP1, GPR126, and HMGA2; and BMI (P values<1x10(-4)): FTO and MC4R. Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI.

SUBMITTER: Liu JZ 

PROVIDER: S-EPMC3232006 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genome-wide association study of height and body mass index in Australian twin families.

Liu Jimmy Z JZ   Medland Sarah E SE   Wright Margaret J MJ   Henders Anjali K AK   Heath Andrew C AC   Madden Pamela A F PA   Duncan Alexis A   Montgomery Grant W GW   Martin Nicholas G NG   McRae Allan F AF  

Twin research and human genetics : the official journal of the International Society for Twin Studies 20100401 2

Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at approximately 550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value=1.06x10(-9)) located in HHIP, a well-replicated height  ...[more]

Similar Datasets

Methylation profiling Epigenome-wide analysis of monozygotic twin pairs discordant for body mass index
2015-04-20 | GSE43975 | GEO
Unknown Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data.
| S-EPMC3664369 | biostudies-literature
Unknown Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry.
| S-EPMC6488973 | biostudies-literature
Unknown Genome-Wide Interaction and Pathway Association Studies for Body Mass Index.
| S-EPMC6504780 | biostudies-literature
Unknown Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children.
| S-EPMC6895864 | biostudies-literature
Unknown Association of Body Mass Index With Colorectal Cancer Risk by Genome-Wide Variants.
| S-EPMC7781451 | biostudies-literature
Unknown Genome-wide association study of body mass index in subjects with alcohol dependence.
| S-EPMC5102811 | biostudies-literature
Unknown Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
| S-EPMC4854022 | biostudies-literature
Unknown A genome-wide association study of body mass index across early life and childhood.
| S-EPMC4469798 | biostudies-literature
Unknown Genome wide association study: searching for genes underlying body mass index in the Chinese.
| S-EPMC4537185 | biostudies-literature