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CSA: comprehensive comparison of pairwise protein structure alignments.


ABSTRACT: CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl.

SUBMITTER: Wohlers I 

PROVIDER: S-EPMC3394275 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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CSA: comprehensive comparison of pairwise protein structure alignments.

Wohlers Inken I   Malod-Dognin Noël N   Andonov Rumen R   Klau Gunnar W GW  

Nucleic acids research 20120502 Web Server issue


CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural  ...[more]

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