Ontology highlight
ABSTRACT:
SUBMITTER: Cole AM
PROVIDER: S-EPMC3394507 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Cole Alicia M AM Ridgway Rachel A RA Derkits Sahra E SE Parry Lee L Barker Nick N Clevers Hans H Clarke Alan R AR Sansom Owen J OJ
EMBO molecular medicine 20101101 11
Senescence has been implicated as an important mechanism of tumour suppression in a number of human malignancies, including colorectal cancer (CRC). However, we still have a relatively poor understanding of how the underlying mutations that occur in cancer cause senescence and its relevance in vivo. The Apc gene is mutated in approximately 80% of CRC as the initiating event, but rarely elsewhere. In this study we have examined the capacity of Apc loss to induce senescence in the intestinal epith ...[more]