Ontology highlight
ABSTRACT:
SUBMITTER: Luheshi NM
PROVIDER: S-EPMC3394668 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Luheshi Nadia M NM McColl Barry W BW Brough David D
European journal of immunology 20091101 11
Sterile inflammation is a host response to tissue injury that is mediated by damage-associated molecular patterns released from dead cells. Sterile inflammation worsens damage in a number of injury paradigms. The pro-inflammatory cytokine IL-1 alpha is reported to be a damage-associated molecular pattern released from dead cells, and it is known to exacerbate brain injury caused by stroke. In the brain, IL-1 alpha is produced by microglia, the resident brain macrophages. We found that IL-1 alpha ...[more]