Ontology highlight
ABSTRACT:
SUBMITTER: Yu W
PROVIDER: S-EPMC3395807 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Yu Wenquan W Gill Tina T Wang Lijuan L Du Yanming Y Ye Hong H Qu Xiaowang X Guo Ju-Tao JT Cuconati Andrea A Zhao Kang K Block Timothy M TM Xu Xiaodong X Chang Jinhong J
Journal of medicinal chemistry 20120629 13
We recently described the discovery of oxygenated N-alkyl deoxynojirimycin (DNJ) derivative 7 (CM-10-18) with antiviral activity against dengue virus (DENV) infection both in vitro and in vivo. This imino sugar was promising but had an EC(50) against DENV in BHK cells of 6.5 μM, which limited its use in in vivo. Compound 7 presented structural opportunities for activity relationship analysis, which we exploited and report here. These structure-activity relationship studies led to analogues 2h, 2 ...[more]