Ontology highlight
ABSTRACT:
SUBMITTER: Yuan J
PROVIDER: S-EPMC3396183 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Yuan Jing J Cheng Ken Chih-Chien KC Johnson Ronald L RL Huang Ruili R Pattaradilokrat Sittiporn S Liu Anna A Guha Rajarshi R Fidock David A DA Inglese James J Wellems Thomas E TE Austin Christopher P CP Su Xin-zhuan XZ
Science (New York, N.Y.) 20110801 6043
Malaria remains a devastating disease largely because of widespread drug resistance. New drugs and a better understanding of the mechanisms of drug action and resistance are essential for fulfilling the promise of eradicating malaria. Using high-throughput chemical screening and genome-wide association analysis, we identified 32 highly active compounds and genetic loci associated with differential chemical phenotypes (DCPs), defined as greater than or equal to fivefold differences in half-maximu ...[more]