Ontology highlight
ABSTRACT:
SUBMITTER: Fukaya T
PROVIDER: S-EPMC3396526 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Fukaya Tomohiro T Murakami Ryuichi R Takagi Hideaki H Sato Kaori K Sato Yumiko Y Otsuka Haruna H Ohno Michiko M Hijikata Atsushi A Ohara Osamu O Hikida Masaki M Malissen Bernard B Sato Katsuaki K
Proceedings of the National Academy of Sciences of the United States of America 20120626 28
Dendritic cells (DCs) are composed of multiple subsets that play a dual role in inducing immunity and tolerance. However, it is unclear how CD205(+) conventional DCs (cDCs) control immune responses in vivo. Here we generated knock-in mice with the selective conditional ablation of CD205(+) cDCs. CD205(+) cDCs contributed to antigen-specific priming of CD4(+) T cells under steady-state conditions, whereas they were dispensable for antigen-specific CD4(+) T-cell responses under inflammatory condit ...[more]