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In vivo analysis of dendritic cell development and homeostasis.

ABSTRACT: Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC network. Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3.

SUBMITTER: Liu K

PROVIDER: S-EPMC2803315 | biostudies-other | 2009 Apr

REPOSITORIES: biostudies-other

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In vivo analysis of dendritic cell development and homeostasis.

Liu Kang K Victora Gabriel D GD Schwickert Tanja A TA Guermonprez Pierre P Meredith Matthew M MM Yao Kaihui K Chu Fei-Fan FF Randolph Gwendalyn J GJ Rudensky Alexander Y AY Nussenzweig Michel M

Science (New York, N.Y.) 20090312 5925

Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs ...[more]

PMID: 19286519

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