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Sensitive biological detection with a soluble and stable polymeric paramagnetic nanocluster.

ABSTRACT: We describe the design, synthesis, and biological characterization of manganese oxocluster-based "single molecule magnets (SMMs)". We demonstrate that polymeric micellar nanoparticles can serve as a carrier and help to stabilize delicate SMM molecules from breaking down easily and thus prevent their property loss. Concentrating thousands of Mn-clusters per micelle provided a high ionic and per-particle relaxivity allowing sensitive MR imaging in vivo. This reports one of the earliest examples of in vivo imaging of a rationally designed polymeric micelle that features SMM.

SUBMITTER: Kim B

PROVIDER: S-EPMC3397310 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Sensitive biological detection with a soluble and stable polymeric paramagnetic nanocluster.

Kim Benjamin B Schmieder Anne H AH Stacy Allen J AJ Williams Todd A TA Pan Dipanjan D

Journal of the American Chemical Society 20120613 25

We describe the design, synthesis, and biological characterization of manganese oxocluster-based "single molecule magnets (SMMs)". We demonstrate that polymeric micellar nanoparticles can serve as a carrier and help to stabilize delicate SMM molecules from breaking down easily and thus prevent their property loss. Concentrating thousands of Mn-clusters per micelle provided a high ionic and per-particle relaxivity allowing sensitive MR imaging in vivo. This reports one of the earliest examples of ...[more]

PMID: 22693958

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