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Radiolabeled ?-AApeptides: a new class of tracers for positron emission tomography.

ABSTRACT: A ?-AApeptide-based tracer for positron emission tomography imaging of integrin ?(v)?(3) is reported. Despite its shorter sequence and linear nature, this tracer had comparable integrin ?(v)?(3) binding affinity to the cyclic arginine-glycine-aspartic acid peptide but significantly higher resistance to enzymatic degradation and better stability.

SUBMITTER: Yang Y 

PROVIDER: S-EPMC3397393 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Radiolabeled γ-AApeptides: a new class of tracers for positron emission tomography.

Yang Yunan Y   Niu Youhong Y   Hong Hao H   Wu Haifan H   Zhang Yin Y   Engle Jonathan W JW   Barnhart Todd E TE   Cai Jianfeng J   Cai Weibo W  

Chemical communications (Cambridge, England) 20120702 63

A γ-AApeptide-based tracer for positron emission tomography imaging of integrin α(v)β(3) is reported. Despite its shorter sequence and linear nature, this tracer had comparable integrin α(v)β(3) binding affinity to the cyclic arginine-glycine-aspartic acid peptide but significantly higher resistance to enzymatic degradation and better stability. ...[more]

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