Ontology highlight
ABSTRACT:
SUBMITTER: Peters BA
PROVIDER: S-EPMC3397394 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Nature 20120711 7406
Recent advances in whole-genome sequencing have brought the vision of personal genomics and genomic medicine closer to reality. However, current methods lack clinical accuracy and the ability to describe the context (haplotypes) in which genome variants co-occur in a cost-effective manner. Here we describe a low-cost DNA sequencing and haplotyping process, long fragment read (LFR) technology, which is similar to sequencing long single DNA molecules without cloning or separation of metaphase chro ...[more]