Ontology highlight
ABSTRACT:
SUBMITTER: Porubsky D
PROVIDER: S-EPMC5670131 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171103 1
The diploid nature of the human genome is neglected in many analyses done today, where a genome is perceived as a set of unphased variants with respect to a reference genome. This lack of haplotype-level analyses can be explained by a lack of methods that can produce dense and accurate chromosome-length haplotypes at reasonable costs. Here we introduce an integrative phasing strategy that combines global, but sparse haplotypes obtained from strand-specific single-cell sequencing (Strand-seq) wit ...[more]