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Design, synthesis, and photochemical validation of peptide linchpins containing the S,S-tetrazine phototrigger.

ABSTRACT: The design, solid-phase synthesis, and photochemical validation of diverse peptide linchpins, containing the S,S-tetrazine phototrigger, have been achieved. Steady state irradiation or femtosecond laser pulses confirm their rapid photofragmentation. Attachment of peptides to the C- and N-termini will provide access to diverse constrained peptide constructs that hold the promise of providing information about early peptide/protein conformational dynamics upon photochemical release.

SUBMITTER: Abdo M

PROVIDER: S-EPMC3397404 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Design, synthesis, and photochemical validation of peptide linchpins containing the S,S-tetrazine phototrigger.

Abdo Mohannad M Brown Stephen P SP Courter Joel R JR Tucker Matthew J MJ Hochstrasser Robin M RM Smith Amos B AB

Organic letters 20120626 13

The design, solid-phase synthesis, and photochemical validation of diverse peptide linchpins, containing the S,S-tetrazine phototrigger, have been achieved. Steady state irradiation or femtosecond laser pulses confirm their rapid photofragmentation. Attachment of peptides to the C- and N-termini will provide access to diverse constrained peptide constructs that hold the promise of providing information about early peptide/protein conformational dynamics upon photochemical release. ...[more]

PMID: 22731895

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Peptide/protein stapling and unstapling: introduction of s-tetrazine, photochemical release, and regeneration of the peptide/protein.

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Project description:This SuperSeries is composed of the SubSeries listed below.

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