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Woodylides A-C, new cytotoxic linear polyketides from the South China Sea sponge Plakortis simplex.

ABSTRACT: Three new polyketides, woodylides A-C (1-3), were isolated from the ethanol extract of the South China Sea sponge Plakortis simplex. The structures were elucidated by spectroscopic data (IR, 1D and 2D NMR, and HRESIMS). The absolute configurations at C-3 of 1 and 3 were determined by the modified Mosher's method. Antifungal, cytotoxic, and PTP1B inhibitory activities of these polyketides were evaluated. Compounds 1 and 3 showed antifungal activity against fungi Cryptococcus neoformans with IC?? values of 3.67 and 10.85 µg/mL, respectively. In the cytotoxicity test, compound 1 exhibited a moderate effect against the HeLa cell line with an IC?? value of 11.2 µg/mL, and compound 3 showed cytotoxic activity against the HCT-116 human colon tumor cell line and PTP1B inhibitory activity with IC?? values of 9.4 and 4.7 µg/mL, respectively.

SUBMITTER: Yu HB

PROVIDER: S-EPMC3397464 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Woodylides A-C, new cytotoxic linear polyketides from the South China Sea sponge Plakortis simplex.

Yu Hao-Bing HB Liu Xiang-Fang XF Xu Ying Y Gan Jian-Hong JH Jiao Wei-Hua WH Shen Yang Y Lin Hou-Wen HW

Marine drugs 20120507 5

Three new polyketides, woodylides A-C (1-3), were isolated from the ethanol extract of the South China Sea sponge Plakortis simplex. The structures were elucidated by spectroscopic data (IR, 1D and 2D NMR, and HRESIMS). The absolute configurations at C-3 of 1 and 3 were determined by the modified Mosher's method. Antifungal, cytotoxic, and PTP1B inhibitory activities of these polyketides were evaluated. Compounds 1 and 3 showed antifungal activity against fungi Cryptococcus neoformans with IC₅₀ ...[more]

PMID: 22822354

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