Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Paez GE
PROVIDER: S-EPMC3397867 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
González-Páez Gonzalo E GE Wolan Dennis W DW
The Journal of biological chemistry 20120529 29
Cysteine protease SpeB is secreted from Streptococcus pyogenes and has been studied as a potential virulence factor since its identification almost 70 years ago. Here, we report the crystal structures of apo mature SpeB to 1.06 Å resolution as well as complexes with the general cysteine protease inhibitor trans-epoxysuccinyl-l-leucylamido(4-guanidino)butane and a novel substrate mimetic peptide inhibitor. These structures uncover conformational changes associated with maturation of SpeB from the ...[more]