Ontology highlight
ABSTRACT:
SUBMITTER: Yu PL
PROVIDER: S-EPMC3397904 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Yu Pei-Lin PL Zhang Zhe-Hao ZH Hao Bai-Xia BX Zhao Yong-Juan YJ Zhang Li-He LH Lee Hon-Cheung HC Zhang Liangren L Yue Jianbo J
The Journal of biological chemistry 20120601 29
Cyclic adenosine diphosphate ribose is an endogenous Ca(2+) mobilizer involved in diverse cellular processes. A cell membrane-permeable cyclic adenosine diphosphate ribose analogue, cyclic inosine diphosphoribose ether (cIDPRE), can induce Ca(2+) increase in intact human Jurkat T-lymphocytes. Here we synthesized a coumarin-caged analogue of cIDPRE (Co-i-cIDPRE), aiming to have a precisely temporal and spatial control of bioactive cIDPRE release inside the cell using UV uncaging. We showed that C ...[more]