'Click cyclic ADP-ribose': a neutral second messenger mimic.
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ABSTRACT:
SUBMITTER: Swarbrick JM
PROVIDER: S-EPMC4047616 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
'Click cyclic ADP-ribose': a neutral second messenger mimic.
Swarbrick Joanna M JM Graeff Richard R Garnham Clive C Thomas Mark P MP Galione Antony A Potter Barry V L BV
Chemical communications (Cambridge, England) 20140123 19
Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca(2+) release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators. ...[more]
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