Contributions of human enzymes in carcinogen metabolism.
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ABSTRACT:
SUBMITTER: Rendic S
PROVIDER: S-EPMC3398241 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Contributions of human enzymes in carcinogen metabolism.
Rendic Slobodan S Guengerich F Peter FP
Chemical research in toxicology 20120510 7
Considerable support exists for the roles of metabolism in modulating the carcinogenic properties of chemicals. In particular, many of these compounds are pro-carcinogens that require activation to electrophilic forms to exert genotoxic effects. We systematically analyzed the existing literature on the metabolism of carcinogens by human enzymes, which has been developed largely in the past 25 years. The metabolism and especially bioactivation of carcinogens are dominated by cytochrome P450 enzym ...[more]
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