Ontology highlight
ABSTRACT:
SUBMITTER: Ring KL
PROVIDER: S-EPMC3399516 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Ring Karen L KL Tong Leslie M LM Balestra Maureen E ME Javier Robyn R Andrews-Zwilling Yaisa Y Li Gang G Walker David D Zhang William R WR Kreitzer Anatol C AC Huang Yadong Y
Cell stem cell 20120607 1
The generation of induced pluripotent stem cells (iPSCs) and induced neuronal cells (iNCs) from somatic cells provides new avenues for basic research and potential transplantation therapies for neurological diseases. However, clinical applications must consider the risk of tumor formation by iPSCs and the inability of iNCs to self-renew in culture. Here we report the generation of induced neural stem cells (iNSCs) from mouse and human fibroblasts by direct reprogramming with a single factor, Sox ...[more]