Ontology highlight
ABSTRACT:
SUBMITTER: Xiao D
PROVIDER: S-EPMC6054649 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Xiao Dongchang D Liu Xiaoning X Zhang Min M Zou Min M Deng Qinqin Q Sun Dayu D Bian Xuting X Cai Yulong Y Guo Yanan Y Liu Shuting S Li Shengguo S Shiang Evelyn E Zhong Hongyu H Cheng Lin L Xu Haiwei H Jin Kangxin K Xiang Mengqing M
Nature communications 20180720 1
Induced neural stem cells (iNSCs) reprogrammed from somatic cells have great potentials in cell replacement therapies and in vitro modeling of neural diseases. Direct conversion of fibroblasts into iNSCs has been shown to depend on a couple of key neural progenitor transcription factors (TFs), raising the question of whether such direct reprogramming can be achieved by non-neural progenitor TFs. Here we report that the non-neural progenitor TF Ptf1a alone is sufficient to directly reprogram mous ...[more]