Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs.
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ABSTRACT:
SUBMITTER: Huang CC
PROVIDER: S-EPMC3400108 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
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Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs.
Huang Chen-Che Jeff CC Yao Humphrey Hung-Chang HH
Molecular reproduction and development 20100601 6
Adrenal, testis, and ovary are steroidogenic organs derived from a common primordium that consists of steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs but also controls their differentiation. Recent evidence implicates the Hedgehog (Hh) signaling pathway as a downstream regulator of SF1 in the appearance of steroidogenic cells in these organs. The Hh signaling pathway serves as a common crosstalk component, yet has evolved div ...[more]
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