DiNuP: a systematic approach to identify regions of differential nucleosome positioning.

ABSTRACT:

Motivation

With the rapid development of high-throughput sequencing technologies, the genome-wide profiling of nucleosome positioning has become increasingly affordable. Many future studies will investigate the dynamic behaviour of nucleosome positioning in cells that have different states or that are exposed to different conditions. However, a robust method to effectively identify the regions of differential nucleosome positioning (RDNPs) has not been previously available.

Results

We describe a novel computational approach, DiNuP, that compares nucleosome profiles generated by high-throughput sequencing under various conditions. DiNuP provides a statistical P-value for each identified RDNP based on the difference of read distributions. DiNuP also empirically estimates the f

SUBMITTER: Fu K 

PROVIDER: S-EPMC3400967 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature